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- Specialty border printed on select covers published in November 1986 celebrating Marvel's 25th Anniversary or more precisely, the 25th year since Fantastic Four #1 was published in November 1961
- 1st full appearance of Gambit, preceded Uncanny X-Men #266 by three weeks
- *confusion regarding Gambit's first appearance: in this issue, Gambit appears in multiple panels, has a conversation with Storm and his name is said
- Agent Venom (Flash Thompson) joins the Secret Avengers
- Death of the fourth Ant-Man (Eric O'Grady), who replaced by a "Life-Model Decoy," robots created by S.H.I.E.L.D