Humberto Ramos
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- 1st appearance of Reverbium, a metal that amplifies sound, opposite of Vibranium
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- Death of Peter Parker in Doc Ock's body
- Doc Ock's consciousness becomes fully seated in Peter Parker's body
- Doc Ock makes the choice to become 'Superior Spider-Man'
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- 1st appearance of Goblin Knight
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- 1st appearance of Devil Spider
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- 1st appearance of Monster (formerly Carlie Cooper), after being exposed to Goblin Formula
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- 1st appearance of Cindy Moon (becomes Silk)
- 1st appearance of Clash
- 1st preview appearance of Lash and Inferno in a back-up story introducing the title 'Inhuman'
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- 1st appearance of Silk, a Korean-American girl who was also bitten by the same radioactive spider as Peter Parker
- 📈 twice as many copies sold versus prior week due to speculation Silk will appear in Spider-Verse 2
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- 1st team appearance and origin of the Champions: Ms. Marvel, Spider-Man, Nova, Hulk, Viv Vision, Cyclops
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- 1st ongoing solo title series featuring Mary Jane
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