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Agents of S.H.I.E.L.D.
- Cameo appearance of Knull, the Symbiote God
- 1st cameo team appearance of the Symbiote Super-Soldiers
- 1st appearance of Rex Strickland, an agent of S.H.I.E.L.D and former member of the Sym-Soldier program
- 1st appearance of the Grendel Symbiote