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Fantastic Four Major Villains
- 1st appearance of Ronan the Accuser, a high-ranking Kree who can trace his ancestry back to the early Kree tribes of Hala
- 1st appearance of the Supreme Intelligence, a collective information system of the greatest Kree minds
- 1st appearance of Mephisto
- * Marvel Hulu supernatural shows are possibly going to include Mephisto and Lilith (Ghost Rider #28 is on The Spec Deck already)