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  • 1st appearance of Toxie Doxie, an ally of Norman Osborn, later becomes the Scarlet Witch
  • 1st appearance of Ai Apaec, the Decapitator, a half-man, half-spider creature captured by Norman Osborn
  • [September 2020 - consider this a longshot, a possible hint in the WandaVision preview comes in the form of a newspaper headline that mentions the birth of a baby named June. June Covington is a character who goes by the name Toxie Doxie in comics, later becoming Scarlet Witch of the Dark Avengers team led by Norman Osborne]
Details
Publisher Marvel
Published January 2011
Written By Kelly Sue DeConnick
Illustrated By Ben Oliver