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Marvel Sep 1963

Amazing Spider-Man #4

Amazing Spider-Man #4
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1st appearance and origin of Sandman
1st appearance of Betty Brant, a secretary at the Daily Bugle
Spider-Man refers to himself as 'The Friendly Neighborhood Spider-Man' for the first time
1st cameo appearance of Jessica Jones, a spectator of the Sandman versus Spider-Man fight - this appearance is retconned as revealed in The Amazing Spider-Man #601
Marvel Jan 2011

Osborn #1

Osborn #1
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$1
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1st appearance of Toxie Doxie, an ally of Norman Osborn, later becomes the Scarlet Witch
1st appearance of Ai Apaec, the Decapitator, a half-man, half-spider creature captured by Norman Osborn

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